Postdoc in Aging and multi-omics data integration (readvertisement)
Novo Nordisk Foundation Center for Basic Metabolic Research
Faculty of Health and Medical Sciences
University of Copenhagen
We are looking for a highly motivated and diligent postdoc for a 5 months’ position to commence as soon as possible.
The Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR)’s vision is to strengthen interdisciplinary research that transforms our basic understanding of the mechanisms that underlie metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. We were established in 2010 and in 2017, we moved into new laboratories, offices, and meeting rooms in the Maersk Tower www.maersktower.ku.dk.
CBMR has around 260 employees who work in an international, highly collaborative research environment across a range of biomedical disciplines. You can read more about us here: www.cbmr.ku.dk.
In the Treebak Group, we aim to define mechanisms linking cellular NAD+ to metabolic health. We want to understand the role of the NAD+ generating and consuming pathways for maintaining tissue function and adaptability in response to metabolic stress. We employ innovative preclinical models to manipulate NAD-related metabolites cell type-specifically and determine functional implications. We have developed several novel and unique experimental models and techniques related to in vivo animal research. Moreover, we apply unbiased omics approaches and analytical pipelines in collaboration with key national and international partners to identify responsible mediators and to determine genotype/phenotype interactions. We are highly motivated and self-driven with a passion for metabolic research. We are part of a strong interdisciplinary, supportive, and diverse environment at CBMR, and we believe that teamwork and engagement are key elements for scientific success. You can read more about the Treebak Group here: Molecular Metabolism in the Treebak Group – University of Copenhagen (ku.dk).
We aim to delineate the common molecular networks involved in the lifespan and health promoting effects of dietary restriction and its mimetics. We have designed a pipeline to determine biologically relevant pathways affected by these interventions. We will analyse the metabolome, transcriptome and miRNome of samples obtained from C. elegans, as well as adipose tissue and serum from mice, rats, and humans after dietary interventions. We will also perform metagenomics analyses of the microbiota of mice, rats, and humans since changes in the microbiome have been associated with the effects of dietary restriction. We will correlate these findings with lifespan and/or metabolic profiling using data integration to identify evolutionarily conserved pathways that are commonly affected. The relevant pathways will then be scrutinized using gain- or loss-of-function models in C. elegans, mice, and mammalian preadipocyte cell lines, providing new insights into how these dietary interventions affect health span in multiple organisms, including humans.
We are looking for a highly motivated and enthusiastic scientist who can perform metagenomic, metabolomic, and transcriptomic data analyses, and integrate this information using relevant methods. The following competencies and experience are important:
Essential experience and skills:
- You have a PhD in Biology, Biochemistry, Molecular Biology, Molecular Biomedicine, or related sciences.
- You are highly experienced in the various omics-type data analyses as mentioned above.
- You are proficient in omics data integration methodologies.
- Proficient communication skills and ability to work in teams.
- Excellent English skills written and spoken.
Desirable experience and skills:
- Solid programming skills in common data analysis or statistical computing languages (preferably in Python, R, or MATLAB).
- Fluent in widely used data-science packages such as NumPy, pandas, matplotlib, scikit-learn, etc.
- Experience in statistical methods and algorithms appropriate for big-data analysis and integration, e.g., multiple testing problem, batch correction, matrix factorization, etc.
Place of employment
The place of employment is at Novo Nordisk Foundation Center for Basic Metabolic Research, Maersk Tower, Panum Institute, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment.
Terms of employment
The employment as Postdoc is a full-time position for 5 months. Starting date is as soon as possible.
Salary, pension, and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.
Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
The position is covered by the Job Structure for Academic Staff at Universities 2020.
For further information please contact Associate Professor Jonas Thue Treebak at firstname.lastname@example.org . For questions regarding the recruitment procedure, please contact HR at email@example.com.
International applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:
- Motivated letter of application (max. one page).
- CV incl. education, work/research experience, language skills and other skills relevant for the position.
- A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
- List of publications.
Deadline for applications: May 29, 2023, at 23.59pm CET.
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The further process
You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.
Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.