Postdoc in Molecular Metabolism – Treebak Group

Novo Nordisk Foundation Center for Basic Metabolic Research
Faculty of Health and Medical Sciences
University of Copenhagen

The University of Copenhagen is seeking a highly motivated and talented postdoctoral fellow to commence October 1, 2021 at the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), University of Copenhagen.

The postdoctoral fellowship is part of the Novo Nordisk Foundation Center for Basic Metabolic Research International Postdoctoral Program www.cbmr.ku.dk/postdocprogram.

About Us
The Novo Nordisk Foundation Center for Basic Metabolic Research’s vision is to strengthen interdisciplinary research that transforms our basic understanding of the mechanisms that underlie metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. We were established in 2010 and in 2017, we moved into new laboratories, offices and meeting rooms in the Maersk Tower www.maersktower.ku.dk.

The Center has around 240 employees who work in an international, highly collaborative research environment across a range of biomedical disciplines. You can read more about us here: www.cbmr.ku.dk.

Our Research and Environment
The overarching goal of our research is to define molecular and physiological mechanisms by which dietary compounds, weight loss, and physical activity improve insulin sensitivity to prevent and treat obesity and type 2 diabetes. We are particularly interested in defining mechanisms linking cellular NAD+ to metabolic health. In particular, we aim to understand the role of the NAD+ generating and consuming pathways for maintaining tissue function and adaptability in response to metabolic stress. We employ innovative preclinical models to manipulate NAD-related metabolites cell type-specifically and determine functional implications. We have developed a number of novel and unique experimental models and techniques related to in vivo animal research. Moreover, we apply unbiased omics approaches and analytical pipelines in collaboration with key national and international partners to identify responsible mediators and to determine genotype/phenotype interactions. We are highly motivated and self-driven with a passion for metabolic research. We are part of a strong interdisciplinary, supportive and diverse environment at the Center, and we believe that team work and engagement are key elements for scientific success. Link to the Treebak Group: https://cbmr.ku.dk/research/integrative-metabolism-and-environmental-influences/treebakgroup/

Job Description
Insulin resistance in peripheral tissues such as skeletal muscle and adipose tissue is characterized by an inability of the target tissue to appropriately modulate glucose disposal in response to a specific level of insulin. Insulin resistance precedes the development of type 2 diabetes (T2D) and is a consequence of ectopic lipid deposition in insulin responsive tissues. NAD+ has emerged as an important cofactor linking energy status with adaptive cellular and organismal responses, and it serves as a substrate for multiple enzymes involved in the regulation of energy metabolism. Low cellular NAD+ levels could therefore prompt the development of many age-related disorders, including insulin resistance. Skeletal muscle act as an important sink for glucose clearance under insulin-stimulated conditions, and insulin signaling to glucose disposal in skeletal muscle in the context of insulin resistance has been studied intensively over many years. We have preliminary data from quantitative mass spectrometric analysis of skeletal muscle that shows key proteins in the insulin signaling cascade are ADP-ribosylated. Since ADP ribosylation (ADPr) is mediated by NAD+-consuming ADP-ribosyltransferases, this indicates a yet unrecognized interplay between insulin signaling and cellular NAD+ metabolism. Our hypothesis is that ADPr plays an essential role in regulating insulin sensitivity in skeletal muscle, and our over-arching aim is to determine the role of this posttranslational modification (PTM) for maintaining cellular glucose homeostasis and insulin action. Your tasks would be to define and compare insulin-induced ADP ribosylomes of insulin sensitive and resistant skeletal muscle, and to identify key modifications that are important for insulin signaling to mediate glucose disposal. We strive to understand the molecular basis for ADPr in skeletal muscle insulin resistance, and we are looking for candidates who are motivated to integrate approaches in in vivo physiology, high-resolution mass spectrometry-based proteomics, and molecular biology.

Profile
The fellowship is aimed at early career researchers with a basic science background. We are particularly interested in candidates who are familiar with integrative research approaches within the broad area of basic metabolic research with an application towards human pathophysiology.

Required qualifications:

  • PhD in Biology, Biochemistry, Molecular Biology, Molecular Biomedicine, or related sciences
  • Excellent scientific track record in relation to career stage
  • Experience in the study of animal physiology, specifically related to in vivo and in vitro metabolic studies using transgenic and knockout models
  • Experience with cell cultures
  • Prior experience in research fields related to insulin signalling/sensitivity and/or ADP-ribosylation would be a clear advantage
  • An analytical aptitude for devising innovative scientific or technical solutions
  • Prior experience in high-resolution mass spectrometry is not essential, but will be considered an advantage
  • Knowledge in bioinformatics and large-scale data analysis, and skills in statistical computational environment such as R and Python will be considered a distinct advantage, but not a requirement
  • The candidate should be able to conduct independent and creative research, demonstrate scientific productivity, and show good inter-personal and communication skills
  • Strong motivation and excellent scientific skills are essential
  • Excellent English communication skills, both written and oral

Eligibility
The CBMR International Postdoctoral Program is open for applicants that hold a PhD degree awarded from a university outside of Denmark. The PhD degree has to be obtained before October 1, 2021. The program is also open for applicants with a Danish PhD degree who can document at least 12 months full-time research experience from outside Denmark. You are not eligible to apply for the program if you have been employed in a postdoctoral position for more than one year at the University of Copenhagen prior to the commencement of the fellowship.

Terms of Employment
The employment as postdoc is a full time position for 3 years. Starting date is October 1, 2021.
Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.
Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

Questions
For further information about the position, please contact Associate Professor Jonas Treebak at jttreebak@sund.ku.dk.
Questions regarding the CBMR International Postdoctoral Program must be directed to cbmr@sund.ku.dk.
For questions regarding the recruitment procedure, please contact HR at sund-hr-cbmr@sund.ku.dk.

The University of Copenhagen International Staff Mobility office offers support and assistance to all international researchers on all issues related to moving to and settling in Denmark. Read more at www.ism.ku.dk.

Application Procedure
Your online application must be submitted in English via the ‘Apply now’ link below. Furthermore, your application must include the following documents/attachments – all in PDF format:

  • Cover letter expressing the motivation and previous research experience of the applicant (max 1 page)
  • Curriculum vitae
  • Copy of the PhD degree certificate and the Master degree certificate. In case the PhD has not yet been completed, a written statement from the supervisor confirming it will be obtained before October 1, 2021 is acceptable.
  • List of publications
  • References (name and contact details of at least two references)

Application Deadline: April 19, 2021, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The Further Process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed, each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at www.employment.ku.dk/faculty/recruitment-process.

The applicant will be assessed according to the Ministerial Order no. 242 of March 13, 2012 on the Appointment of Academic Staff at Universities.

The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of their personal background.

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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

Jonas Thue Treebak

Info

Application deadline: 19-04-2021
Employment start: 01-10-2021
Working hours: Full time
Department/Location: Novo Nordisk Foundation Center for Basic Metabolic Research
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