Postdoc in AMPK signaling in circadian metabolism
Novo Nordisk Foundation Center for Basic Metabolic Research
Faculty of Health and Medical Sciences
University of Copenhagen
The University of Copenhagen is seeking a highly motivated and talented postdoctoral fellow to commence October 1, 2021 at the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), University of Copenhagen.
The postdoctoral fellowship is part of the Novo Nordisk Foundation Center for Basic Metabolic Research International Postdoctoral Program www.cbmr.ku.dk/postdocprogram.
The Novo Nordisk Foundation Center for Basic Metabolic Research’s vision is to strengthen interdisciplinary research that transforms our basic understanding of the mechanisms that underlie metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. We were established in 2010 and in 2017, we moved into new laboratories, offices and meeting rooms in the Maersk Tower www.maersktower.ku.dk.
The Center has around 240 employees who work in an international, highly collaborative research environment across a range of biomedical disciplines. You can read more about us here: www.cbmr.ku.dk.
The successful candidate will interact closely with two supervisors at CBMR, namely Profs. Juleen R. Zierath and Kei Sakamoto. The Zierath Group investigates the interactions between intrinsic biorhythms and external perturbations such as exercise and nutrient provision to identify novel translational strategies for prevention and treatment of metabolic disease: https://cbmr.ku.dk/research/integrative-metabolism-and-environmental-influences/zierath-group/.
The Sakamoto Group investigates fundamental molecular signaling mechanisms that control energy metabolism and glucose homeostasis associated with exercise, insulin resistance and type 2 diabetes: https://cbmr.ku.dk/research/nutrient-and-metabolite-sensing/sakamoto-group/.
An essential component of an organism’s survival is the ability to sense energy availability and to adapt accordingly. As such, cells contain highly conserved sensing mechanisms that monitor energy and nutrient status. These energy sensors are tightly linked with endogenous circadian rhythms and thereby contribute to the plasticity of liver, adipose tissue and skeletal muscle to maintain metabolic homeostasis throughout the day. AMP-activated protein kinase (AMPK) is a crucial cellular energy and nutrient sensor, which integrates stimuli such as metabolites, growth factors, and energy status. Results from our group suggest that AMPK may be required as an energetic sensing mechanism controlling circadian core clock gene expression and metabolism. The main objective of this post-doctoral project is to determine the mechanism by which energetic stressors converge on AMPK signaling and the circadian machinery and elucidate the potential role of AMPK in influencing metabolic communication between tissues. The post-doctoral fellow will adopt multi-disciplinary approaches, integrating cell-based systems and animal models to validate whether AMPK pathways are involved the clock-controlled changes in systemic metabolism. This project will also include usage of transcriptomic and metabolomics platforms, as well as bioinformatics tools, and the successful candidate will therefore receive necessary basic training within these fields. Proteomics studies will be carried out in collaboration with the Deshmukh Group at the Center.
The fellowship is aimed at early career researchers with a basic science background or clinicians who aspire to a career in academic medicine. We are particularly interested in candidates who are familiar with integrative research approaches within the broad area of basic metabolic research with an application towards human pathophysiology.
- PhD in Biology, Biochemistry, Molecular Biology, Molecular Biomedicine, or related sciences
- Knowledge of mitochondrial respiration, mammalian metabolism and circadian biology
- Documented experience with animal handling
- Demonstrated experience with mammalian tissue culture techniques and biochemical assays
- Experience with high resolution mass spectrometry and bioinformatics analysis is desirable
- The candidate should be able to work independently and interactively in a team setting, and be enthusiastic, motivated and proactive
- Excellent English communication skills, both written and oral
The CBMR International Postdoctoral Program is open for applicants that hold a PhD degree awarded from a university outside of Denmark. The PhD degree has to be obtained before October 1, 2021. The program is also open for applicants with a Danish PhD degree who can document at least 12 months full-time research experience from outside Denmark. You are not eligible to apply for the program if you have been employed in a postdoctoral position for more than one year at the University of Copenhagen prior to the commencement of the fellowship.
Terms of Employment
The employment as postdoc is a full time position for 3 years. Starting date is October 1, 2021.
Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.
Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
For further information about the position, please contact Professor Kei Sakamoto, firstname.lastname@example.org. Questions regarding the CBMR International Postdoctoral Program must be directed to email@example.com. For questions regarding the recruitment procedure, please contact HR at firstname.lastname@example.org.
The University of Copenhagen International Staff Mobility office offers support and assistance to all international researchers on all issues related to moving to and settling in Denmark. Read more at www.ism.ku.dk.
Your online application must be submitted in English via the ‘Apply now’ link below. Furthermore, your application must include the following documents/attachments – all in PDF format:
- Cover letter expressing the motivation and previous research experience of the applicant (max 1 page)
- Curriculum vitae
- Copy of the PhD degree certificate and the Master degree certificate. In case the PhD has not yet been completed, a written statement from the supervisor confirming it will be obtained before October 1, 2021 is acceptable.
- List of publications
- References (name and contact details of at least two references)
Application Deadline: April 19, 2021, 23.59pm CET
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The Further Process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed, each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at www.employment.ku.dk/faculty/recruitment-process.
The applicant will be assessed according to the Ministerial Order no. 242 of March 13, 2012 on the Appointment of Academic Staff at Universities.
The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of their personal background.
Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.