3-year Postdoc position in stem cell-based disease modelling of Parkinson’s Disease

Department of Neuroscience

Faculty of Health and Medical Sciences

University of Copenhagen

 

The Human Neural Development research group at the Department of Neuroscience, led by PI Agnete Kirkeby, is seeking candidates for an open 3-year Postdoc position with start from January 1st, 2021 or as soon as possible thereafter.  

The position is to study stem cell-based modelling of retrotransposon activation in Parkinson’s Disease.

Job description 
The candidate shall perform a scientific project as part of an international consortium to study the role of transposable elements (TEs) in the development of Parkinson’s disease. The project will involve the controlled activation of TEs in human pluripotent stem cells through the use of a lentiviral CRISPRa-based system, and subsequent investigation of the neuroimmunological consequence of TE activation in complex 3D neural models containing neurons, astrocytes and microglia. You can read more about the project here:

https://parkinsonsroadmap.org/research-network/neuro-immune-interactions/

https://www.stemcellcenter.lu.se/article/researchers-to-investigate-the-role-of-transposable-elements-in-neuroinflammation-and-parkinsons-disease.

The candidate will be applying the following techniques – among others - in the project: Human pluripotent stem cell culturing and differentiation to neurons, astrocytes and microglia, 3D neural organoid models, lentiviral CRISPRa-based genetic manipulation, high-throughput qRT-PCR, single cell RNA sequencing, immunofluorescence imaging and inflammatory cytokine measurements.

Candidate qualifications
The candidate must hold a PhD degree in biology, neurobiology, biomedical sciences or similar, and possess a good understanding of neurobiology, with particular emphasis on stem cell biology and/or neuroinflammation. Practical experience in working with human pluripotent stem cells and neural differentiation is a requirement. Experience in working with organoid culturing, lentiviral constructs, CRISPR-based genetic modification, neuroinflammation/microglia, immunofluorescent staining, qRT-PCR, and confocal imaging are all considered as great advantages. Good English communication skills, both oral and written, are required.

The research environment 
You will be part of an innovative and highly collaborative research environment in the group of Human Neural Development (The Kirkeby group,
https://in.ku.dk/research/kirkeby-lab/) at University of Copenhagen. Our research facilities are placed at the Department of Neurosceince in a newly built, highly modern research building, the Maersk Tower, located at the heart of Copenhagen. The Human Neural Development group consists of a research team of 11 team members at University of Copenhagen and 4 team members at University of Lund. The two teams work closely together to combine their expertise in stem cell differentiation, neurotransplantation and animal models of disease. The Kirkeby group works on various different projects within the field of neuroregeneration, including the development of stem cell therapies for neurodegenerative diseases, studies on human brain development using complex 3D and microfluidic culturing techniques and generation of pure cultures of specific subtypes of human neurons for disease modelling.

The postdoc candidate will form part of an international consortium including also the groups of Johan Jakobsson (University of Lund), Roger Barker (University of Cambridge) and Molly Hammel (Cold Spring Harbor Laboratory), and the position is funded by the newly established Aligning Science Across Parkinson’s (ASAP) initiative: https://parkinsonsroadmap.org/.  The candidate will therefore be part of a highly competitive international network, and will interact frequently with both consortium members as well as members of other international ASAP-funded consortia.

Terms of employment
The employment as postdoc is a full time and fixed-term position for 3 years. Starting date is January 1st 2021 or as soon as possible thereafter.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 34,600 DKK/ approx. 4,650 Euro (April 2020-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the Job Structure for Academic Staff at Universities 2020.

Questions
For further information, please contact associated professor Agnete Kirkeby, agnete.kirkeby@sund.ku.dk, https://sund.ku.dk/.

Foreign applicants may find this link useful: https://www.ism.ku.dk/ (International Staff Mobility).

Application
The application must be submitted in English and it must contain following documents:

  • Application letter, including motivations for applying for this position and a brief summary of previous research experience (maximum 2 pages)
  • Curriculum vitae, including (but not limited to):
    • Education
    • Previous and current positions
    • List of honours, awards and fellowships
    • Research supervision and teaching 
    • Research projects in which you have participated
    • Technical skills
    • Overview summary or publications, patent applications and conference presentations
    • Public outreach activities, i.e. popular lectures or other activities engaging the general public
  • Diplomas (Master and PhD degree or equivalent)
  • Full list of publications and info about total number of publications (peer reviewed/non-peer reviewed), H factor and number of citations (Google Citation or Web of Science), including also patent applications

The application, in English, must be submitted electronically by clicking APPLY NOW below. 

Deadline for application: 10th November 2020

Application procedure
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee.  All applicants are then immediately notified whether their application has been passed for assessment. The Dean then appoints an expert assessment committee in order to make an assessment of the selected applicants for the specific posts. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at https://jobportal.ku.dk/.

Please note that the applicant will be contacted if the assessment committee requires further documentation.

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

 

 

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

APPLY NOW

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

Agnete Kirkeby

Info

Application deadline: 10-11-2020
Employment start: 01-01-2021
Working hours: Full time
Department/Location: Institut for Neurovidenskab

Search all vacancies