Postdoc in Molecular Pharmacology

Novo Nordisk Foundation Center for Basic Metabolic Research

University of Copenhagen

 

The University of Copenhagen seeks a highly motivated and talented postdoctoral fellow to commence October 1, 2020 at the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen.

The postdoctoral fellowship is part of the Novo Nordisk Foundation Center for Basic Metabolic Research International Postdoctoral Program www.cbmr.ku.dk/postdocprogram.

About Us
The Novo Nordisk Foundation Center for Basic Metabolic Research’s vision is to strengthen interdisciplinary research that transforms our basic understanding of the mechanisms that underlie metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. We were established in 2010, and in 2017 we moved into new laboratories, offices and meeting rooms in the Maersk Tower www.maersktower.ku.dk.

The Center has around 200 employees who work in an international, highly collaborative research environment across a range of biomedical disciplines. You can read more about us here: www.cbmr.ku.dk.

Our Research
A 3-year postdoctoral fellowship is available in the group of Thomas Frimurer. The focus of the Frimurer group (https://cbmr.ku.dk/research/nutrient-and-metabolite-sensing/frimurer-group/), is related to translational pharmacology and rational design of next generation drugs. We use structure-based design technologies to develop pharmacological tool compounds and early drug candidates, which are used to characterize the physiological role of metabolic target proteins for prevention and treatment of obesity and type 2 diabetes. This project will be conducted in close collaboration with the Metabolic Pharmacology group of Professor Birgitte Holst (https://bmi.ku.dk/english/Staff/?pure=en/persons/5009) at the Department of Biomedical Sciences and researchers at the Novo Nordisk Foundation Center for Protein Research. (https://www.cpr.ku.dk). As a postdoc in this research area, you will be part of this highly ambitious interdisciplinary collaboration with the goal of optimizing and using in-house developed tool compounds to evaluate the physiological function of a novel metabolic target enzyme (ADAMTS-9) in insulin resistance and type 2 diabetes.

Job Description

Type 2 diabetes is determined by a complex interplay between environmental and genetic factors. Using a combination of human genetic and transgenic animal studies - the potential role of ADAMTS-9 in glucose metabolism and insulin sensitivity has only recently been established by researchers at CBMR (Anne-Sofie Graae., et al. Diabetes 2019 68:502-514). Our findings contribute to the understanding of the molecular mechanisms underlying insulin resistance and type 2 diabetes and point to inhibition of ADAMTS-9 as a potential novel mode of treating insulin resistance.

Your primary goal will be to evaluate the physiological role of ADMATS-9 in regulating insulin resistance. You will be the main driver to develop cell-based functional assays of increasing complexity and use our in-house developed tool compounds to characterize the role of ADAMTS-9 mediated signalling on intracellular effectors downstream of the integrin and insulin receptor pathway. Based on this knowledge, we aim to investigate how ADAMTS-9 impairs insulin sensitivity, mitochondria function and glucose homeostasis in vitro, ex vivo and in vivo proof-of-concept studies.

Profile

The fellowship is aimed at early career researchers with a basic science background or clinicians who aspire to a career in academic medicine. We are particularly interested in candidates who are familiar with integrative research approaches within the broad area of basic metabolic research with an application towards human pathophysiology.

Required qualifications:

  • PhD in Biology, Human Biology, Biochemistry, Molecular Biology, Molecular Biomedicine, or related sciences
  • Excellent scientific track record in relation to career stage
  • Experience working independently in a laboratory setting and a broad understanding of biology
  • Knowledge of extracellular matrix modulation and intracellular signalling mechanisms (such as those downstream of the integrin and insulin pathways) is an advantage.
  • Expertise with in vitro, ex vivo and in vivo models and work with animals is essential.
  • Excellent English communication skills, both written and oral

Eligibility

The CBMR International Postdoctoral Program is open for applicants that hold a PhD degree awarded from a university outside of Denmark. The program is also open for applicants with a Danish PhD degree who can document at least 12 months full-time research experience from outside Denmark. You are not eligible to apply for the program if you have been employed in a postdoctoral position for more than one year at the University of Copenhagen prior to the commencement of the fellowship.

Terms of Employment

The employment as postdoc is a full-time position for 3 years. Starting date is October 1, 2020.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

Questions

For further information about the position, please contact Associate Professor Thomas Frimurer at thomas.frimurer@sund.ku.dk. Questions regarding the CBMR International Postdoctoral Program must be directed to cbmr@sund.ku.dk. For questions regarding the recruitment procedure, please contact HR at sund-hr-cbmr@sund.ku.dk.

The University of Copenhagen International Staff Mobility office offers support and assistance to all international researchers on all issues related to moving to and settling in Denmark. Read more at www.ism.ku.dk.

Application Procedure

Your online application must be submitted in English via the ‘Apply now’ link below. Furthermore, your application must include the following documents/attachments – all in PDF format:

  • Cover letter expressing the motivation and previous research experience of the applicant (max 1 page)
  • Curriculum vitae
  • Copy of the PhD degree certificate and the Master degree certificate. In case the PhD has not yet been completed, a written statement from the supervisor is acceptable.
  • List of publications
  • References (name and contact details of at least two references)

 
Application Deadline: March 22, 2020, 23.59pm CET
 
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
 
The Further Process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed, each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
 
You can read about the recruitment process at www.employment.ku.dk/faculty/recruitment-process.
 
The applicant will be assessed according to the Ministerial Order no. 242 of March 13, 2012 on the Appointment of Academic Staff at Universities.
 
The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of their personal background.

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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

Thomas Michael Frimurer

Info

Application deadline: 22-03-2020
Employment start: 01-10-2020
Working hours: Full time
Department/Location: Novo Nordisk Foundation Center for Basic Metabolic Research

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