Postdoc in Mass-spectrometry-based Secretomics

Novo Nordisk Foundation Center for Basic Metabolic Research

University of Copenhagen

The University of Copenhagen seeks a highly motivated and talented postdoctoral fellow to commence October 1, 2020 at the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen.

The postdoctoral fellowship is part of the Novo Nordisk Foundation Center for Basic Metabolic Research International Postdoctoral Program

About Us

The Novo Nordisk Foundation Center for Basic Metabolic Research’s vision is to strengthen interdisciplinary research that transforms our basic understanding of the mechanisms that underlie metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. We were established in 2010, and in 2017 we moved into new laboratories, offices and meeting rooms in the Maersk Tower

The Center has around 200 employees who work in an international, highly collaborative research environment across a range of biomedical disciplines. You can read more about us here:

Our Research

The current position is in the Program for Integrative Physiology and Environmental Influences headed by Prof. Juleen Zierath. The Zierath Group investigates the interactions between intrinsic biorhythms and external perturbations such as exercise, nutrient availability and temperature to identify potent translational strategies for prevention and treatment of metabolic diseases ( The successful candidate will work closely with the Deshmukh Group at CBMR and with Prof. Harriet Wallberg-Henriksson at Karolinska Institutet, Stockholm, Sweden. The successful candidate will integrate proteomics and functional physiology to map adipose tissue secretome in response to exercise training. He or she will be embedded within CBMR and work in a scientific environment that bridges several disciplines of proteomics and metabolic diseases.

Job Description

Adipose tissue plays an important role in mediating the health-promoting effects of exercise training. The beneficial effects of exercise are associated with adipose tissue browning and the modification of its lipid and secretory profile. However, in humans, the molecular mechanisms driving adipose tissue adaptation(s) to exercise, as well as the relevance of adipose tissue and adipose tissue-derived signals in the metabolic response to exercise, remain unclear.

Our overarching hypothesis for this postdoctoral project is that physical activity is beneficial for women with disturbed lipolysis, and that exercise-induced secreted proteins helps protect against long-term body weight gain and cardiometabolic complications. Your task would be to apply mass-spectrometry-based proteomics to map a signature of adipose tissue secretome in a) untrained pre-menopausal women, b) untrained and habitually exercising postmenopausal women, and c) response to an acute exercise bout in pre and postmenopausal women. Follow-up studies involve investigating the role of the shortlisted candidate secreted proteins in vitro and in vivo metabolism in human and murine cell systems and mouse models. You are expected to: 1) culture primary adipocytes from the adipose tissue biopsies collected by our collaborators at Karolinska Institutet, Stockholm and 2) perform functional assays in human, murine cell systems and mouse models to characterize the role of potential secreted proteins. You will get assistance with proteomics analysis but you are expected to master the proteomics workflow for secretomics analysis during your fellowship.


The fellowship is aimed at early career researchers with a basic science background or clinicians who aspire to a career in academic medicine. We are particularly interested in candidates who are familiar with integrative research approaches within the broad area of basic metabolic research with an application towards human pathophysiology.

Required qualifications:

  • PhD in Biology, Biochemistry, Molecular Biology, Molecular Biomedicine, or related sciences
  • Basic understanding of adipose and mitochondrial biology and mammalian metabolism
  • Documented experience in primary adipose tissue culturing (working with human adipose tissue is an advantage), immunohistochemistry, cell-sorting using FACS, immunoblotting, siRNA, qPCR, mitochondrial respiration by Seahorse, glucose uptake and fatty acid oxidation assays in cellular models.
  • Documented experience with animal handling
  • Experience with high resolution mass spectrometry, proteomics sample preparation, secretomics and bioinformatics analysis is desirable
  • Excellent English communication skills, both written and oral


The CBMR International Postdoctoral Program is open for applicants that hold a PhD degree awarded from a university outside of Denmark. The program is also open for applicants with a Danish PhD degree who can document at least 12 months full-time research experience from outside Denmark. You are not eligible to apply for the program if you have been employed in a postdoctoral position for more than one year at the University of Copenhagen prior to the commencement of the fellowship.

 Terms of Employment

The employment as postdoc is a full-time position for 3 years. Starting date is October 1, 2020.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.


For further information about the position, please contact Associate Professor Atul Deshmukh at Questions regarding the CBMR International Postdoctoral Program must be directed to For questions regarding the recruitment procedure, please contact HR at

The University of Copenhagen International Staff Mobility office offers support and assistance to all international researchers on all issues related to moving to and settling in Denmark. Read more at

Application Procedure

Your online application must be submitted in English via the ‘Apply now’ link below. Furthermore, your application must include the following documents/attachments – all in PDF format:

  • Cover letter expressing the motivation and previous research experience of the applicant (max 1 page)
  • Curriculum vitae
  • Copy of the PhD degree certificate and the Master degree certificate. In case the PhD has not yet been completed, a written statement from the supervisor is acceptable.
  • List of publications
  • References (name and contact details of at least two references)

Application Deadline: March 22, 2020, 23.59pm CET
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The Further Process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed, each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at
The applicant will be assessed according to the Ministerial Order no. 242 of March 13, 2012 on the Appointment of Academic Staff at Universities.
The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of their personal background.


Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.


Juleen R Zierath


Application deadline: 22-03-2020
Employment start: 01-10-2020
Working hours: Full time
Department/Location: Novo Nordisk Foundation Center for Basic Metabolic Research

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