Postdoc in Experimental Pharmacology

at Department of Veterinary and Animal Science

Faculty of Health and Medical Sciences

University of Copenhagen

 

Section of Experimental Animal Models at the Department of Veterinary and Animal Science wishes to appoint a postdoc within experimental pharmacology from 1 May 2020 (or soon thereafter) until 30 April 2022.

The Faculty of Health and Medical Sciences and Novo Nordisk A/S jointly establish a research centre in 2010 – The LIFEPHARM Centre – with a budget of DKK 140 mill covering activities until the end of 2023. The present position is part of the Centre’s activities. The purpose of the research centre is to strengthen the research in experimental pharmacology and toxicology and to increase the output of postdocs and PhDs with a strong in vivo pharmacological profile. It is expected that the future post doc will actively participate in and support the Centre’s activities. For further information on the Centre see www.lifepharm.dk

The project

It is well known that metabolic active organs secrete hormones and other factors that communicate energy availability to the hypothalamus and other areas of the brain. Hormones from the adipocytes and the GI-tract, such as Leptin and GLP-1, respectively, have over the years been characterized for pharmacological potential as anti-obesity interventions. Less focus has been on the liver-secreted factors, despite the fact that hepatocytes are highly important for nutrient sensing and metabolism. New compounds are being identified that are expressed in the liver, and where the hepatocytes are responsible for their regulated secretion. This project investigates how nutritional status of the liver interacts with the satiety signalling of the brain. The project is a collaboration between Section of Experimental Animal Models and Department of Biomedical Sciences, University of Copenhagen and Novo Nordisk. We offer creative and stimulating working conditions in dynamic and international research environment.

Your job
The candidate will in collaboration with the supervisors, be responsible for the design of the in vivo as well as the ex vivo studies. The job also includes performance of the experimental work, which covers dosing of compounds (orally, s.c, i.p and by osmotic pumps) to rodents as well as evaluation of the in vivo metabolic phenotype including use of calorimetric chambers. The ex vivo characterization of the tissue including western blot, QPCR and plasma analyses of hormones, is also part of the basis work tasks. Finally, together with the supervisors the candidate will be responsible for evaluation and analyse of the data and writing the data into manuscripts.

Profile
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:

Essential experience and skills:

  • You have a PhD in experimental pharmacology, physiology, human biology, medicine, veterinary medicine or similar
  • You are an experienced experimentalist with abilities to work independently in a laboratory setting
  • You have a European ABD accreditation
  • Proficient communication skills and ability to work in teams
  • Excellent English skills written and spoken

Desirable experience and skills:

  • Knowledge of in vivo pharmacological methods and ex vivo pharmacological methods to evaluate metabolic status of the tissue using western blot, QPCR, and immunohistochemistry.
  • Knowledge of handling of proteomic and transcriptomics data.

Terms of employment
The employment as postdoc is a full time and fixed-term position for two years. Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 33,600 DKK/ approx. 4,480 Euro (April 2018-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Ministerial Order on the Job Structure of Academic Staff at Universities” of 11 December 2019.

Questions
For further information please contact Professor Jens Lykkesfeldt (jopl@sund.ku.dk] or Professor Birgitte Holst (holst@sund.ku.dk). Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page).

2. CV incl. education, work/research experience, language skills and other skills relevant for the position.

3. A certified/signed copy of a) PhD certificate, b) Master of Science certificate and c) ABD accreditation. If the PhD is not completed, a written statement from the supervisor will do.

4. List of publications.

Application deadline:  19 February 2020, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in week 12.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

Birgitte Holst

Contact

Jens Lykkesfeldt
E-mail: jopl@sund.ku.dk

Info

Application deadline: 19-02-2020
Employment start: 01-05-2020
Working hours: Full time
Department/Location: Institut for Veterinær- og Husdyrvidenskab

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