Postdoc in Spatial RNA Characterization Cancer Microenvironments, Department of Biology/BRIC, Faculty of Science, University of Copenhagen

A 2-year postdoctoral position is open from June 1st 2020 or as soon as possible thereafter, in the project MICROGRAD: A new generation of microfluidics-based methods to study genetic and functional effects of complex spatiotemporal gradients in tumor microenvironments.

Research environment  

The project is a highly interdisciplinary collaboration between four groups, located at the Department of Biology, Faculty of Science (Prof. Albin Sandelin, Prof. Stine F. Pedersen,), the Technical University of Denmark (Assoc. Prof. Rodolphe Marie) and Federal Institute for Materials Research and Testing, Berlin (Prof. Ute Resch-Genger). The candidate will be based in Albin Sandelin’s group, but will work closely with the other groups, especially two postdoctoral fellows hired in parallel in the Falsig Pedersen and Marie groups. Together, the groups employ multiple postdocs, PhD students, and undergraduate students and provide a strong, international research environment.  

Research project and postdoc qualifications

The tumor microenvironment fundamentally impacts tumor cell behavior, but cannot currently be accurately mimicked in vitro. This project will develop and apply a new generation of microfluidic devices that allow constitution of spatiotemporally precise gradients of acidosis and hypoxia, key properties of the tumor microenvironment. The devices will be validated using fluorescent reporters, and will be used to determine the phenotypic and RNA expression responses of tumor cells to the tumor microenvironment.

The postdoc will be responsible for all work on this project in the Sandelin lab and for coordinating the close collaboration with the three other groups. In particular, the focus will be to optimizing methods to measure RNA expression from wells in the microfluidics device using spatial transcriptomics. The Sandelin laboratory is a joint wet and dry lab focusing on medical and fundamental transcriptomics (see www.sandelinlab.org). Highlights from the lab include:

  1. Anderson and Sandelin: Determinants of enhancer and promoter activities of regulatory elements. Nature Reviews Genetics 2019
  2. Boyd et al: Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies. Nature Communications 2018
  3. Chen et al: Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters. Nature Genetics 2016
  4. Arner et al: Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science 2015
  5. Andersson et al: An atlas of active enhancers across the human body. Nature 2014

The ideal candidate has a background in RNA/molecular biology and/or genomics and strong expertise in methods development in genomics. Expertise in biophysics, microfluidics, bioinformatics and/or cancer biology is an advantage.

Other essential requirements are a PhD in a life science field, a documented track record of strong scientific publications, and excellent written and spoken English. The candidate must be able to work autonomously as well as in a team and have a passion for working in a highly interdisciplinary environment.  

Further information on the Department is linked at http://www.science.ku.dk/english/about-the-faculty/organisation/. Inquiries about the position can be made to Professor Albin Sandelin (albin@binf.ku.dk).  

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

Terms of employment

The position is covered by the Memorandum on Job Structure for Academic Staff.

Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.

The starting salary is currently up to DKK 434.179 including annual supplement (+ pension up to DKK 74.244). Negotiation for salary supplement is possible.

The application, in English, must be submitted electronically by clicking APPLY NOW below.

Please include

  • Cover letter
  • Curriculum vita
  • Diplomas (Master and PhD degree or equivalent)
  • Complete publication list
  • Separate reprints of 3 particularly relevant papers

The deadline for applications is March 25, 2020, 23:59 GMT +1.

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.

APPLY NOW

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Info

Application deadline: 25-03-2020
Employment start: 01-06-2020
Working hours: Full time
Department/Location: Department of Biology

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