Postdoc in Vascular Biology at Department of Biomedical Sciences

We are looking for a highly motivated and dynamic researcher for a 2 year postdoc position commencing in May 2020 who will investigate the role of microtubules in hypertension.

The fellow will study the molecular contribution of the microtubule network to hypertension in arteries using the state-of-the-art techniques including, but not limited to, isometric and pressure myography, gene knockdown/editing systems, confocal/super-resolution microscopy, in situ proximity ligation assays, and animal disease models.

Information on the department can be found at: https://bmi.ku.dk/english/research/the-vascular-biology-group/

 Our research
The Vascular Biology Group is a fast growing, interdisciplinary team, dedicated to understanding vascular physiology and pathophysiology.

We are interested in the cells that control the diameter of arteries, namely smooth muscle cells, which can contract and relax. In hypertension and atherosclerosis, hyper-contractility and restructuring of arterial smooth muscle cells leads to increased arterial tone and/or reduced blood flow. In the smooth muscle cells, several membrane proteins display altered function and expression, but without an understanding of how their membrane expression is controlled, development of new therapeutics to treat hypertension remains a distant dream. Our research will investigates trafficking mechanisms of specific membrane proteins, such as ion channels and receptors, which are dysregulated in vascular disease.

Your job
The Vascular Biology Group is investigating the cells that control the diameter of arteries, namely smooth muscle cells, which can contract and relax. Within these cells, is a cellular 'road' network termed the microtubule network, which moves proteins around the cell to ensure it contracts and relaxes properly. Smooth muscle cells are often dysfunctional in hypertension but very little is known about the microtubule network, particularly in hypertensive blood vessels. Your job is to investigate microtubule regulation of arterial tone and determine whether targeting microtubules can help treat hypertension.

Teamwork is extremely important within the Vascular Biology Group. Your will be expected to work closely with several PhD students on different areas of microtubule-related vascular biology. Your main task would be to identify if and how our novel microtubule findings contribute to the pathogenesis of hypertension.  Since we are a multidisciplinary team, it is important you are open and enjoy working with others on the same project.

Profile
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:

Essential experience and skills:

  • You have a PhD in Physiology (preferably vascular background) or molecule biology (preferable involving microtubule research).
  • You are highly experienced in either cardiovascular physiology or microtubule biology.
  • You have an active interest to learn and discover. We need you to be highly experienced in either cardiovascular physiology or microtubule biology, therefore we you must show determination and work hard to strengthen and develop your skills in the area in which you do not have experience.
  • Proficient communication skills and ability to work in teams
  • Excellent English skills written and spoken

Desirable experience and skills:

  • It is necessary that you have experience and knowledge of working with animals and dissections to apply for this position.
  • It is necessary that your PhD included research within either vascular physiology or microtubule biology.
  • Desirable - experience in molecular biology techniques including (but not limited to): mass spectrometry, proximity ligation assays, immunostaining, live cell imaging, super-resolution microscopy.
  • Desirable - Knowledge of Western blotting, co-immunoprecipitation assays.

Place of employment
The place of employment is at Department of Biomedical Sciences, Panum Institute, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories, an integrative cardiovascular physiology environment and access to excellent imaging facilities.

Terms of employment
The employment as postdoc is a full time and fixed-term position for 2 years. Starting date is May 2020.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 33,600 DKK/ approx. 4,480 Euro (April 2018-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.

Questions
For further information please contact Thomas Jepps; tjepps@sund.ku.dk. Applications submitted by email will not be considered. Please follow the application procedure below.

Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore your application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page).

2. CV incl. education, work/research experience, language skills and other skills relevant for the position.

3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.

4. List of publications.

 

Application deadline:  31st March 2020, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

 

Interviews are expected to be held in week beginning 20th April 2020

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

 

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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Info

Application deadline: 31-03-2020
Employment start: 01-05-2020
Working hours: Full time
Department/Location: Biomedicinsk Institut

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