advanced crystallographic studies of lytic polysaccharide monooxygenases
Department of Chemistry
Faculty of Science
A two year
position is available to study lytic polysaccharide monooxygenases (LPMOs) by advanced crystallographic methods in the
group of Prof. Leila Lo Leggio. LPMOs are a relatively newly discovered class
of copper metalloenzymes able to degrade recalcitrant polysaccharides (see
reviews at http://journals.iucr.org/m/issues/2016/06/00/be5273/
ndex.html and https://doi.org/10.1042/BST20170549
have been studying the structure and function of these enzymes in collaboration
with academic and industrial partners for a number of years.
research activities will primarily focus on ‘kinetic’ crystallography
approaches aimed to further elucidate the mechanism or mechanisms by which
LPMOs can break glycosidic bonds oxidatively. The approaches to be taken will
include both trapping of intermediates to be studied by ‘conventional’
crystallography and truly time-resolved techniques such as Laue diffraction and
serial crystallography, including use of spectroscopic methods to follow the
reaction. The postdoctoral researcher may also get involved in neutron
diffraction studies that have been initiated by a PhD student in the
in structure determination by macromolecular crystallography is an absolute
requirement for the successful applicant. Additionally, previous experience
with spectroscopic analysis of reaction mechanisms and/or crystallographic
intermediate trapping and/or time-resolved studies by diffraction techniques
are strongly desired qualifications. Previous research on carbohydrate
modifying enzymes and/or copper enzymes is additionally qualifying.
researcher activities will be integrated with the other research activities of
the group on LPMOs. Funding of the position comes from an Independent Research
Fund (DFF) grant to Prof. Leila Lo Leggio and the project is additionally
integrated with the HOPE project (including a larger constellation of
researchers in Denmark working on LPMOs, https://ign.ku.dk/hope/
). Leila Lo
Leggio’s laboratory is part of ISBUC (Integrated Structural Biology at the
University of Copenhagen https://isbuc.ku.dk/
The postdoc’s duties will include primarily research
within the project and a minor component of teaching duties. The post may also
include performance of other duties.
The position is
open with starting date no later than
1. October 2019 and preferably earlier.
University wishes our staff to reflect the diversity
of society and thus welcomes applications from all qualified candidates
regardless of personal background.
The position is
covered by the Memorandum on Job Structure for Academic Staff.
appointment and payment accord to the agreement between the Ministry of
Finance and The Danish Confederation of Professional Associations on Academics
in the State.
salary is currently up to DKK 426.625 including annual supplement (+ pension up
to DKK 72.952). Negotiation for salary supplement is possible.
in English, must be submitted electronically by clicking APPLY NOW below.
(Master and PhD degree or equivalent)
plan – this is meant as a short description of your ideas with regard to
possible approaches to the advertised research area. If employed, these
approaches and ideas will need to be aligned with the existing project
description and plan within the grant.
-Complete publication list
reprints of 3 particularly relevant papers
The deadline for applications is 24. April 2019, 23:59 GMT +1
the expiry of the deadline for applications, the authorized recruitment manager
selects applicants for assessment on the advice of the Interview Committee.
Interviews will be held in end of May/ frist of June.