The Division of Cell
and Gene Therapy of the Center for Translational Neuromedicine (CTN) is looking
for an experienced and highly motivated Research Assistant to join the
Leukodystrophies work group. The successful candidate must be interested and
engaged academically in neuroscience, particularly in its translational applications.
This position targets candidates with a Master’s degree interested in gaining
more experience prior to pursuing an academic career in Neuroscience.
Our research team
The Center for
Translational Neuromedicine is part of the Faculty of Health and Medical Sciences,
University of Copenhagen, and is located in the Panum Institute. For more
information, visit https://ctn.ku.dk/
The successful candidate will integrate the Leukodystrophies group
which focus is the study of the congenital disorders of myelin primarily
affecting children. We generate humanized cell-based models of glial and myelin
disorders with the goal to understand disease pathogenesis and to develop
treatment strategies deemed to be clinically translatable. We are interested in
defining the differences in the dynamic regulation of genes and signaling
pathways in glial precursor cells, as a way to identify novel therapeutic
targets and strategies. We evaluate the behavior of affected cells in vivo upon transplantation in the
mouse brain with the ultimate goal to assess the feasibility of replacing them
by “healthy” glial progenitor cells, generating a proof of concept for
Job description and responsibilities
We are looking for a candidate who will be performing
daily experiments in the group and who will integrate our team as an
interactive member, bringing enthusiasm and ideas to the work being developed. Prior
experience in neuroscience is mandatory. Ability to interpret the
experimental results and formulate plans integrated with the up-to-date
literature in the field is expected.
The experiments conducted in the group involve
primarily (but are not limited to):
- Culture of human pluripotent stem cells and its derivation towards glial fate
- Flow cytometry
- DNA and RNA extraction
- PCR and qPCR
- Immunocytochemistry and immunohistochemistry
- Mouse brain surgery (certificate to work with animals within the Danish universities is mandatory)
- Cryopreservation and cryosectioning of biological materials
- Fluorescence microscopy and data analysis
Experience with all or as many of the techniques
listed above is highly desirable.
Additionally, proactivity and independence to setup and troubleshoot new
protocols as new experiments are designed is expected to be taken as an attractive
challenge. Upon starting the contract, an initial period of training will
follow until the candidate reaches familiarity and independency with the lab’s
protocols. The ability to find a balance between learning fast and working
independently, in one hand, while being able to freely ask questions when
unsure about some aspects of the work is extremely important for the
well-functioning of the team.
The group is currently composed of a group leader, one
research assistant and one scholarship student. We aim to expand the group to
allow the investigation of more disorders under the scope of the
leukodystrophies. The team is hard-working and the work environment is friendly
with a good team work among all members.
- Master’s degree in Human Biology or similar field
- Prior experience and interest in neuroscience
- Highly motivated candidate, passionate by science and driven to be part of translational efforts;
- Language: fluent in English (written and verbal)
- Good scientific writing in English;
- FELASA certificate for animal use;
- Well-organized, independent and pro-active;
- Mature and calm under pressure
The position is covered
by the Memorandum on Job Structure for Academic Staff. Terms of appointment and
payment is according to the agreement between the Ministry of Finance and
The Danish Confederation of Professional Associations on Academics in the
Working hours are 37
hours per week. Flexibility to adjust the schedule to the timings of
experiments is expected and very important.
This is a one-year
position, with the possibility of extension after the one-year assessment.
candidate will report to Joana Osorio (group leader) and Steve Goldman
Start date: As soon as
Your application in
English must be submitted by clicking 'Apply now'.
Application deadline is
20 February 2019.
applications will be accepted and must include:
- Curriculum vitae
- Motivated application
- Copy of relevant diplomas
- Names and contact information of 3 references, with associated letters of recommendation
20 February 2019.