Postdoc in Nutritional Immunology and Parasitology
|Department of Veterinary and Animal Sciences (IVH), Section of Parasitology and Aquatic Pathobiology, wishes to appoint a postdoc in the area of Nutritional Immunology and Parasitology for two years. The position is available from 1 May 2019, or as soon as possible thereafter.
The effect of diet on immune function and gut health is of increasing relevance due to rising antimicrobial resistance in livestock production as well as increasing prevalence of chronic inflammation and diet-related disorders in humans. We have found that certain dietary components may reduce inflammation and modulate immune function during infection with gastrointestinal parasites (
for more information see https://ivh.ku.dk/english/research/about_parasitology_and_aquatic_diseases/pigh/). Here, we will purify bioactive plant compounds and test their activity in in vitro cell culture models of inflammation, and in mouse and pig models of gastrointestinal infection with parasites.
The postdoc will 1) isolate selected dietary components and assess their bioactivity activity using in vitro cell-culture-based assays, transcriptomics and functional cell biology experiments.
2) Carry out an in vivo studies to assess how bioactive dietary supplements modulate mucosal immune function and metabolic function during colonization with parasites.
This 2-year postdoc is part of a 4-year project (2018-22) funded by The Independent Research Fund Denmark (IRFD). The project involves collaborators in the USA and Canada. The successful candidate will be a member of the Parasites, Immunology and Gut Health group at IVH. https://ivh.ku.dk/english/research/about_parasitology_and_aquatic_diseases/pigh/
The postdoc will be expected, in collaboration with PhD fellows and senior researchers, to plan and conduct experiments to test immune-modulating activity of a number of bioactive compounds using in vitro cell-based models, and conduct mechanistic experiments to determine how cellular responses are modified using RNA-seq and functional assays. Subsequently, studies will be carried out in mice to test these immune-modulating effects in vivo, as well as effects on the gut microbiota and metabolome. The postdoc will be required to spend a period of time (around 5 months in total) at collaborating labs in Wisconsin, USA and Quebec, Canada. Other travel for meetings and conferences may be required. The postdoc will also contribute to some pre- and post-graduate teaching within the section.
Essential criteria for the assessment of candidates
The candidate should have:
Applicants possessing some of the following professional and personal qualifications will be highly advantaged:
· Experience with cell-based assays, standard immunology and/or molecular biology techniques (e.g. flow cytometry, qPCR, Western blotting)
· Knowledge of HPLC-MS and/or metabolomics
· Experience in working with mouse models
· Experience within experimental nutrition, parasitology or microbiology
· Well-developed collaborative skills and a team player
The position is available for a 2-year period for applicants holding a relevant degree.
Terms of employment
Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organisations. The position is covered by the Job Structure for Academic Staff at Universities (2013).
Place of work
The main place of work will be at the Department of Veterinary and Animal Sciences, University of Copenhagen at Frederiksberg Campus. Travel in relation to guest visits or stays at other international research institutions and international conferences will be part of the position as well as meetings in Denmark.
For further information about the position, please contact Associate Professor Andrew R Williams by phone (+45-31383122) or email (firstname.lastname@example.org).
The application must be written in English and include the following appendices:
In addition to the material that the applicant wishes to have included in the assessment, the Assessment Committee may include further material in their assessment of the applicant. In such circumstances, it is the responsibility of the applicant, on request, to send the material to the Committee.
The application will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.