A highly attractive postdoctoral position is available in the Choudhary
Group at the Novo Nordisk Foundation Center for Protein Research (CPR – www.cpr.ku.dk
), University of Copenhagen.
About the Choudhary group and CPR
The “Proteomics and Cell Signaling” group at CPR is led by Group Leader
Prof. Chunaram Choudhary. The Choudhary group combines quantitative proteomics,
cell biology and biochemistry to investigate cell signaling at a
“systems-level” and to identify novel regulatory mechanisms in cell signaling.
The group applies cutting-edge mass spectrometry (MS)-based technologies
for unbiased identification and quantification of posttranslational
modifications, such as ubiquitylation, phosphorylation and acetylation (Narita
et al. Nat Rev Mol Cell Biol 2019; Weinert and Narita et al., Cell 2018; Scholz et al., Nat Biotech 2015; Choudhary et al., Nat
Rev Mol cell Biol 2014 and
2010; Weinert et al., Mol Cell 2013; Povlsen and Beli et
Cell Biol 2012; Beli et al. Mol Cell 2012; Choudhary et al. Science 2009). Furthermore, the group uses CRISPR-based genome editing for functional
investigations and for mapping protein-protein interactions in the context of
chromatin-associated processes, such as DNA damage repair (Gupta et al., Cell 2018; Thorslund et al., Nature 2015; Wild et al., Cell
Rep 2016 and 2018). In addition to the state-of-the-art mass
spectrometry, the laboratory is equipped with the cutting-edge infrastructure for
molecular biology, cell biology and biochemistry work.
CPR offers the latest technologies and expertise for quantitative
proteomics, the next-generation nucleic acid sequencing, high-resolution
microscopy, live cell imaging, as well as biophysical and structural characterization
of proteins, including Cryo-EM. Our group is technically and internationally
diverse and embedded in excellent environment for high-quality research and
collaboration. The group consistently publishes in top-ranked journals and has an
outstanding track-record in training the next generation of researchers
(more than 50 % of former postdocs from the group were recruited as independent
investigators at top-ranked institutes). The group collaborates with top-level
international researchers and works closely with other groups at CPR,
especially with the “Clinical Proteomics” group led by Prof. Matthias Mann.
We are now looking for a highly motivated and qualified postdoc candidate
to join our research group.
will use a combination of the cutting-edge proteomics and CRSPR-based genome
editing methods to investigate cell signaling networks in genetically defined
cell models. Among other tasks, this will include CRISPR-based generation of genetically
modified human cell lines, affinity-tagging of endogenous proteins, mass
spectrometry-based analysis of protein-protein interactions and proteome-wide
quantification of posttranslational modifications. The candidate is expected to
apply various biochemical and molecular biology approaches for biological
follow-up experiments on novel and interesting findings derived from
large-scale proteomic screens.
Tentative start date: Spring 2019.
The candidate should have demonstrated excellent scientific productivity,
evidenced by high-quality research publications, be able to conduct independent
and creative research, and show good inter-personal and communication skills.
candidate is required to have a PhD degree or equivalent in natural or
scientific track-record, including at least one publication as first
author in a high-quality, peer reviewed international journal.
knowledge in one or more of the following areas would be considered an
- Analysis of
cell signaling with biochemistry
and molecular biology approaches.
- Genetics and cell biology.
- Analysis of
large-scale proteomic and/or genomic dataset.
integrity, DNA damage repair, chromatin biology, gene transcription.
experience in high resolution mass spectrometry is not essential.
communication skills, both oral and written.
analytical aptitude for devising innovative scientific or technical
enthusiasm, motivation, flexibility and confidence.
Place of employment and work
The employment is at CPR (www.cpr.ku.dk
), University of
Copenhagen, located in central Copenhagen. In the past 10 years, CPR has
established itself as a top-level research institute in protein signaling and
network biology research. The research environment at CPR is ambitious and
international, with approx. 30 different nationalities currently represented.
The Center comprises modern laboratories, supercomputer resources and
state-of-the-art facilities within protein science, including microscopy, cryo-EM,
and the next generation sequencing. Seminars with high-profile international
speakers and regular internal research seminars are organized at the Center. Denmark
is often ranked as the happiest nation and Copenhagen is consistently ranked as
one of the best cities for living.
For more information on working and living
in Denmark visit www.ism.ku.dk
(International Staff Mobility) and https://www.workindenmark.dk/
Terms of salary and employment
Salary, pension and terms of employment will be in
accordance with the agreement between the Ministry of Finance and The Academics
Central organization. Currently, the monthly salary is approx. DKK 33,700 (approx.
EUR 4,500) plus 17.1 % in pension contribution.
The Danish Ministry of Finance and the Danish Confederation of Professional
Associations (AC) have agreed on a protocol that makes it possible for all
international researchers employed by the University to achieve a pension
exemption, where the pension will be paid out as salary.
Duration: The duration of the positions is 2 years with
a possible extension for up-to two years (depending on the performance and
previous employment at the University of Copenhagen).
Your application must be
submitted electronically by clicking ‘APPLY NOW’ below.
Your application should include the following
- Cover letter.
- Curriculum vitae, incl. educational qualifications,
experience and a list of publications where it shows that the candidates have
published at least one publication as first author.
- A scanned copy of the final degree (PhD or
equivalent) certificate. If the degree is not yet awarded, it is sufficient to
mention in the cover letter when the applicant expects to submit thesis, and/or
receive the qualifying degree.
- Names and contact details for 2-3 referees.
The applicants can submit these materials in the given
fields in the online submission system. We reserve the right not to consider
material received after the deadline, and not to consider applications that do
not live up to the above-mentioned requirements and that do not have a least
one publication as first author.
Deadline for application: February 25, 2019.
After the expiry of the application deadline, the
authorized recruitment manager selects applicants for assessment on the advice
of the Appointments Committee. All applicants are then immediately notified
whether their application has been passed for assessment by an expert
assessment committee. Selected applicants are notified of the composition of
the committee and each applicant has the opportunity to comment on the part of
the assessment that relates to the applicant him/herself. You can read about
the recruitment process at www.employment.ku.dk .
For further information about the process or
if you experience any technical difficulty with the online submission system,
please contact SUND HR: firstname.lastname@example.org
CPR and the
University of Copenhagen wish to reflect the diversity of society and welcome
applications from all qualified candidates regardless of personal background.