PhD fellowship in ‘Molecular mechanisms of replication-coupled DNA-protein crosslink repair’ at the Center for Chromosome Stability (CCS), Department of Cellular and Molecular Medicine (ICMM)
A PhD fellowship is available in the Center for Chromosome Stability (CCS) (www.ccs.ku.dk) in a group headed by Assoc. Prof. Thomas Miller. The post is available from 1st June, 2024, or after agreement. Highly motivated and committed candidates with an interest in eukaryotic DNA replication, DNA damage repair, cryogenic electron microscopy (cryo-EM) or single-molecule studies are encouraged to apply. The post is fully funded, although the post-holder will be encouraged to seek a personal fellowship to support their PhD stipend.
The Center for Chromosome Stability
The CCS is a Center of Excellence funded by the Danish National Research Foundation (DNRF) and its mission is to advance our understanding of how chromosomal instability causes human disease. The CCS is embedded at the Department of Cellular and Molecular Medicine (https://icmm.ku.dk/english/). The working language in the CCS is English.
Our group and research
The Miller group (https://icmm.ku.dk/english/research-groups/miller-group/) aims to understand the molecular mechanisms that maintain eukaryotic genome stability during DNA replication using a combination of genetic, biochemical, single-molecule and structural techniques, including cryo-EM. The research in the Miller group is generously supported by a Novo Nordisk Foundation Hallas-Møller Emerging Investigator grant, the Danish National Research Foundation (DNRF) and the Carlsberg Foundation.
Genome instability is a hallmark of inherited human disorders and age-related diseases such as neurodegeneration and cancer. Eukaryotic genomes are replicated by complex molecular machines called replisomes, which frequently encounter naturally occurring ‘obstacles’ that can prevent faithful DNA replication and induce genome instability. Covalent DNA-protein crosslinks (DPCs) are one such obstacle and are estimated to occur at thousands of sites/genome/day in proliferating cells. Eukaryotic cells require multiple mechanisms to overcome DPCs, including replication-coupled proteolysis (‘DPC repair’).
The Miller laboratory aims to determine the molecular mechanisms by which the replication machinery can overcome obstacles on eukaryotic chromosomes that might otherwise prevent replication fork progression. Multiple projects are currently available in the group and can be tailored to fit the experience and interests of the recruited individual.
The recruited researcher will benefit from access to cutting-edge biochemistry, computational and single-molecule infrastructure at the Center for Chromosome Stability (incl. state-of-the-art C-Trap optical tweezers) and electron microscopy facilities at the Core Facility for Integrated Microscopy (CFIM; www.cfim.ku.dk), which houses Copenhagen’s node of the Danish Cryo-EM Facility. The projects will be overseen by Assoc. Prof. Thomas Miller.
Start: 1st June, 2024, (or at a mutually agreed date)
Duration: 3 years as a PhD fellow.
Your key tasks as a PhD student at SUND are:
- Carry out an independent research project under supervision.
- Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points.
- Participate actively in the local research environment.
- Obtain experience with teaching or other types of dissemination related to your PhD project.
- Write a PhD thesis on the grounds of your project.
We are looking for a highly motivated and enthusiastic person with the following competences and experience:
- Must show evidence of publication-standard research, preferable within the areas of protein biochemistry or structural biology.
- Strong communication and collaboration skills, including the ability to work well in an international academic setting.
- Ability to work in a team of multidisciplinary scientists, and the potential to work independently with limited direction.
- Excellent written and oral communication skills in English.
Key criteria for the assessment of candidates
Applicants must have qualifications corresponding to a master’s degree Biochemistry, Biology, Biomedicine or similar (equivalent of the Danish candidate, 3 + 2 years) related to the subject area of the project.
Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted.
As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database. Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science.
Other important criteria are:
- Grade point average achieved
- Professional qualifications relevant to the PhD programme
- Previous publications
- Relevant work experience in DNA replication or repair, structural biology or biochemistry
- Other professional activities
- Curious mind-set with a strong interest in chromosome biology and cryo-electron microscopy
- Personal drive and commitment to science
- Excellent English language skills
Place of employment
The place of employment is at Department of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic, collaborative and international research environment. Our research facilities include modern laboratories and access to state-of-the-art equipment including Titan Krios and Glacios electron microscopes for single particle EM, and C-trap optical tweezers for single-molecule biochemical and biophysical studies.
Terms of employment and employment
The employment as a PhD fellow is full time (37 working hours per week in average) and for 3 years. Starting date is June 1, 2024, or after agreement.
The post is conditional upon the candidate’s successful enrolment in the PhD school at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project, which will be formulated by the candidate in consultation with their supervisors during an initial employment as a research assistant.
The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the University’s rules on achieving the degree. Salary, pension, and terms of employment are in accordance with the agreement between the Danish Ministry of Taxation and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around DKK 28,993 / approx. EUR 3.891 EUR (October 2023-level) plus pension.
For specific information about the PhD fellowship, please contact Thomas Miller by e-mail: email@example.com.
General information about PhD programs at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/.
Your application must be submitted electronically by clicking "Apply now". The application must include the following documents in PDF format:
- Letter of motivation (max. one page)
- CV incl. education, experience, language skills and other skills relevant for the position
- A certified/signed copy of Master of Science certificate. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor will do
- Publication list (if possible).
Application deadline: Sunday 31 March 2024, 23.59 p.m. CET.
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.
The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.
Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/.
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
The Faculty of Health and Medical Sciences comprises approximately 7,800 students and approx. 5,800 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community.
The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position.
Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.