PhD fellows in Protein Science
Department of Biology
Faculty of Science
University of Copenhagen
Department of Biology, Faculty of Science at University of Copenhagen is offering up to two PhD scholarships in protein science commencing 01.10. 2020 or as soon as possible thereafter.
Description of the scientific environment
The positions are funded by the Danish Research Councils (Denmark) and the Thon foundation (Norway) and the students will be integrated as part of the Novo Nordisk Foundation Challenge Center REPIN- rethinking protein interactions. REPIN connects research groups in Copenhagen and Zürich to study interactions of Intrinsically Disordered Proteins (IDPs) using a suite of biophysical methods and ranging from the single atom and molecule over ensembles to organisms. REPIN is also associated with the Linderstrøm-Lang Centre for Protein Science, and is situated in the Biocenter, Department of Biology, University of Copenhagen.
Context constitutes an overarching concept being of physicochemical, biomolecular, and physiological nature, but it also includes the immediate molecular context of an interaction. For IDPs, which often function by exploiting short linear motifs, context contributes in highly regulatory and decisive manners and constitutes a yet largely unrecognized source of interaction potential in a multitude of biological processes. The projects will seek to promote the understanding of the role of flanking regions and context for discriminative binding, mapping mechanisms and specificity via kinetics and thermodynamics, as well as determining structures and ensembles. One project will focus on charge and charge patches in disordered regions in transcription factors and the other on disordered proteins interacting with large DNA clamps, such as proliferating cell nuclear antigens and the beta-clamp. The latter project is part of the TAMiR initiative (Targeting AMR by inhibition of bacterial stress responses) funded by Trond Mohn Stiftelsen, and involves collaborations with researchers in Norway.
The position is available for a 3-year period and your key tasks as a PhD student at SCIENCE are:
To manage and carry through your research project
- Attend PhD courses
- Write scientific articles and your PhD thesis
- Teach and disseminate your research
- To stay at an external research institution for a few months, preferably abroad
- Work for the department
We are seeking highly motivated applicants with an MSc degree or similar in chemistry, biophysics, biochemistry or related fields with the following competences:
- Protein expression and purification including optimization of protocols
- Good oral and written English competences
It will be highly advantageous to have one or more of the following qualifications:
Hands-on experience with biophysical techniques as ITC, stopped-flow, CD or fluorescence spectroscopy or small angle X-ray scattering (not just from courses)
- Protein NMR spectroscopy including set-up and spectral analyses
- Structural biology
- Computation and/or applied bioinformatics
- Publications in peer-reviewed scientific journals
- exciting and stimulating research projects in a strong international academic environment
- an open and inclusive work environment with dedicated colleagues
- personal developments
Terms of employment
The position is covered by the Memorandum on Job Structure for Academic Staff.
Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.
The starting salary is currently at a minimum DKK 331,125 (approx. €43,750) including annual supplement (+ pension at a minimum DKK 53,811). Negotiation for salary supplement is possible.
The application, in English, must be submitted electronically by clicking APPLY NOW below.
- Cover Letter, stating which PhD project you are applying for and detailing your motivation and background for applying for the specific PhD project.
- CV including a list of peer-reviewed publications (may include papers under review or submitted)
- Diploma and transcripts of records (BSc and MSc)
- Contact details for 1-2 former employers or supervisors
- Other information for consideration, e.g. list of publications (if any)
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
The deadline for applications is 10th August 2020, 23:59 GMT +1.
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. Afterwards an assessment committee will be appointed to evaluate the selected applications. The applicants will be notified of the composition of the committee and the final selection of a successful candidate will be made by the Head of Department, based on the recommendations of the assessment committee and the interview committee.
The main criterion for selection will be the research potential of the applicant and the above-mentioned skills. The successful candidate will then be requested to formally apply for enrolment as a PhD student at the PhD school of Science. You can read more about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.
For further information about the PhD positions, please contact Professor Birthe B. Kragelund (email@example.com) or Professor Karen Skriver (KSkriver@bio.ku)
General information about PhD programmes at SCIENCE is available at http://www.science.ku.dk/phd.
Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.