Postdoc position in Primary cilia and pH-regulatory ion transport proteins

Postdoc position in Primary cilia and pH-regulatory ion transport proteins

Department of Biology
Faculty of Science

University of Copenhagen

Description of the project

Most cells in our body contain antenna-like structures on their surface called primary cilia, which are important for regulating cell-cell communication and thereby the development and function of our organs. Defects in cilia can lead to severe human diseases called ciliopathies, which often affect the kidneys. The aim of this project is to investigate how two pH-regulatory ion transporters, NBCn1 and NHE1, are targeted to the primary cilium of mammalian kidney cells, and how they regulate pH within the cilium. NBCn1 and NHE1 regulate essential processes in our cells and organs and their dysfunction is linked to diseases like cancer and hypertension, but it is not clear how they get localized to and function at cilia. Likewise, intraciliary pH and its possible effect on ciliary function are unknown. The results will provide new insight into fundamental cellular trafficking mechanisms, the regulation and subcellular functions of NBCn1 and NHE1, and into how pH may affect cilia-mediated signaling.

The project is a collaboration between the Cilia Group and the NHE1 Group, both of which are located in the August Krogh Building, and is funded by a 3-year grant from the Novo Nordisk Foundation. The postdoc’s duties will include research within the above-described field as well as teaching/student supervision. The post may also include performance of other duties.

Further information on the Department is linked at https://www.science.ku.dk/english/about-the-faculty/organisation/. Inquiries about the position can be made to Professor Lotte Bang Pedersen (E-mail: lbpedersen@bio.ku.dk) or Professor Stine Falsig Pedersen (E-mail: sfpedersen@bio.ku.dk).

The position is open from 1st of June, 2023 or as soon as possible thereafter.

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

Terms of employment

The position is covered by the Memorandum on Job Structure for Academic Staff.

Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.

The application, in English, must be submitted electronically by clicking APPLY NOW below.

Please include

• Curriculum vitae
• Diplomas (Master and PhD degree or equivalent)
• Complete publication list

The deadline for applications is 10th of April, 2023, at 23:59 GMT +2.

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/.