Postdoc position in computational stem cell biology at BRIC

Faculty of Health and Medical Sciences
University of Copenhagen

The Jensen group at BRIC and DanStem has an open postdoc position for a highly motivated and talented researcher with a background in bioinformatics to study the role of stem cells in tissue regeneration. We are recruiting for a 3-year position and we are looking for candidates, who will be able to join our team during summer 2021. The recruited postdoc will work closely with other members of our highly international team to address the role of specific cell populations in colonic tissue regeneration as well as signalling pathways involved in tissue repair using state-of-the-art methodologies including single-cell RNA sequencing, fate mapping, organoid models and genetic mouse models.

Our research/The group
The epithelial tissues along our entire body have to establish an important barrier to protect from the hostile environment. This is achieved via the balanced production of differentiated offspring from resident stem cell populations. Dysregulation of this fine balance lies at the root of diseases such as ulceration and cancer. In the Jensen lab we use a combination of animal models and patient derived material to address fundamental questions related to the formation, maintenance and regeneration of epithelial tissues. Here we use a range of interdisciplinary approaches and technologies to identify and characterize candidate genes regulating cell fate changes (Wong et al., 2012, Nature Cell Biology; Fordham et al., 2013, Cell Stem Cell; Page et al., 2013; Yui et al., 2018, Cell Stem Cell; Cell Stem Cell; Guiu et al., 2019, Nature; Andersen et al., 2019, Nature Cell Biology).

For more information on the Jensen group please follow the link: https://www.bric.ku.dk/research-groups/Research/jensen_group/

Your job
We are looking for an ambitious postdoctoral candidate with a strong background in bioinformatics/computational biology, who is interested in establishing a mathematical model describing cell fate during tissue regeneration in the intestinal epithelium. In the Jensen lab you will be an integral part of a small sub-team with clearly defined individual objectives and research goals. Using state-of-the-art cell biology tools, genetic mouse models and genome engineering, you will help us develop a framework based on computational analysis of single cell RNA sequencing data and quantitative fate mapping data. Depending on your interest this could also include turning the framework into an open source tool/package The work will bridge human and mouse regeneration, and help determine which key regulatory mechanisms control changes in cell fate decisions.

Profile
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:

Essential experience and skills:

  • You are a highly self-motivated and ambitious scientist
  • You have a PhD in Bioinformatics or computational biology
  • You have an excellent track record with at least 1 peer reviewed first author paper in a high-impact journal
  • You have a strong background in bioinformatics and computational biology, and it will be regarded as an advantage if you have experience with analysis of single cell data
  • You have the ability to independently envision, plan and execute a research project
  • You have excellent technical skills
  • You have excellent English skills written and spoken

Place of employment
The place of employment is at BRIC, Biocenter, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and a number of core facilities including a single cell core and a CRIPSR platform facilities shared between the 23 research groups at BRIC and the neighboring Finsen Laboratory. We have weekly journal clubs, data clubs, seminars with invited speakers and a young researchers club ASAP and our own PhD programme, MoMeD and our own https://www.bric.ku.dk/phd-and-postdoc-programme/postdoc-career-programme/. BRIC actively participates in the European alliance, EU-life consisting of 13 excellent life science research institutions http://eu-life.eu/. The Jensen group is also affiliated with DanStem (https://danstem.ku.dk).

Terms of employment
The employment as postdoc is [a full time and fixed-term position for 3 years. Starting date is 1 August 2021 or after agreement

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 34,600 DKK/ approx. 4,650 Euro (february 2021-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of December 11,2019.

Questions
For further information please contact Professor Kim Jensen on e-mail kim.jensen@bric.ku.dk

Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore your application must include the following documents/attachments – all in PDF format:

  1. Motivated letter of application (max. one page).
  2. CV incl. education, work/research experience, language skills and other skills relevant for the position.
  3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
  4. List of publications.

Application deadline: 31 May 2021, 23.59pm CET 

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/.

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in last part of June.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

 

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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

Kim Bak Jensen

Info

Application deadline: 31-05-2021
Employment start: 01-08-2021
Working hours: Full time
Department/Location: Biotech Research & Innovation Centre
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