PhD-positions – University of Copenhagen

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PhD fellow in Medicinal Chemistry

Department of Drug Design and Pharmacology
Faculty of Health and Medical Sciences (SUND)
University of Copenhagen

Department of Drug Design and Pharmacology is offering a three-year PhD fellowship in Medicinal Chemistry. The PhD fellowship is jointly financed by the European Research Council and the Department of Drug Design and Pharmacology. The fellowship will commence 01.06.2017 or as soon as possible.

Project description
Recently, enzymes formerly thought to be protein lysine deacetylases, have now been shown to target different types of lysine modifications including succinyl, glutaryl, and myristoyl. A certain type of hydrolases in human cells, called sirtuins, have been shown to target these modifications, and based on this knowledge, the objective of the current project is to design novel sirtuin inhibitors. The tasks during this project will thus include chemical synthesis, compound characterization, enzymatic inhibition profiling, and cell culture work. In this interdisciplinary way, we will evaluate dependence of various regulatory mechanisms on post-translational acylation of lysine residues.

Principal supervisor
Professor Christian A. Olsen, Center for Biopharmaceuticals and Department of Drug Design and Pharmacology
E-mail: cao@sund.ku.dk

Required qualifications
As an applicant you must have:
•Obtained a Master´s degree in chemistry, pharmacy or chemical engineering prior to the starting date
•Fluency in English and excellent communication skills

Preferred qualifications
We are looking for a highly motivated individual with a strong background in organic synthesis. The applicant should also have strong theoretical education in organic chemistry, biochemistry, medicinal chemistry, and spectroscopy. Hands-on experience with enzymology and molecular biology methods will be seen as favorable.

Job description
Your key tasks as a PhD fellow at the Faculty are to:
•Carry through an independent research project under supervision
•Write scientific articles and the PhD thesis on the grounds of your research project
•Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
•Obtain experience with teaching or other types of dissemination related to your PhD project
•Participate in the undergraduate teaching of students in pharmaceutical sciences
•Participate in national and international congresses and scientific meetings
•Stay at an external research institution, preferably abroad

Key criteria for the assessment of applicants
•Professional qualifications relevant to the PhD programme
•Relevant work experience
•Previous publications
•The grade point average achieved
•Other professional activities
•Language skills
•The successful applicant is also required to be enterprising and to possess good interpersonal skills

Formal requirements
The successful applicant will be requested to formally apply for enrolment as a PhD student at the Faculty of Health and Medical Sciences according to the rules stipulated in the Ministerial order on the PhD programme at the universities (PhD order) from the Ministry of Science, Innovation, and Higher Education and the guidelines for the PhD programme at the Faculty of Health and Medical Sciences.

The PhD student is expected to be affiliated to the graduate programme in pharmaceutical sciences, Drug Research Academy.

Terms of employment
The position as a PhD fellow is available for a 3-year period.

Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organizations. The position is covered by the Protocol on Job Structure.
Minimum monthly salary is DKK 25,555.59 (taxable) + pension contribution.

Application procedure
The application, in English, must be submitted electronically by clicking APPLY NOW below.
Your application must include:

•Cover letter: Letter stating the interest in and qualifications for the project (max. one page)
•Full CV
•Diploma and transcripts of records: Master´s degree diploma (including grade transcripts for bachelor´s and master´s degrees). Applicants with a Master´s degree from abroad should also enclose a short description of the grading scale used
•Possible publication list
•Other information to consider: Possible references and recommendations

The University of Copenhagen wishes to encourage everyone interested in this post to apply, regardless of personal background.

Deadline for applications
31.03.2017
. Please note that only online applications will be accepted.
Applications received later than this date will not be considered.

Post application procedure
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee.
All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee.
Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at employment.ku.dk

The Appointments Committee consists of the supervision group and the Head of Department who is the authorized recruitment manager. The Expert Assessment Committee consists of the principal supervisor.

An answer as to the granting of the fellowship can be expected approx. 4 weeks after application deadline.

Questions
For further information, applicants may contact the supervisor or Administrator Marianne W. Jørgensen, e-mail: marianne.joergensen@sund.ku.dk, direct phone: +45 3533 6449.

For more information on working and living in Denmark visit ism.ku.dk (International staff mobility) and www.workindenmark.dk
SØG STILLINGEN

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

Christian Adam Olsen
E-mail: cao@sund.ku.dk

Info

Ansøgningsfrist: 31-03-2017
Ansættelsesform: Tidsbegrænset periode
Ansættelsesdato: 01-06-2017
Afdeling/Sted: Department of Drug Design and Pharmacology

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