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Postdoc in Glial Biology to Center for Translational Neuromedicine - Division of Glial Disease and Therapeutics

A Postdoc position is available at the Center for Translational Neuromedicine (CTN) at the University of Copenhagen, located at the Panum Institute. The position is open for 2 years with the possibility of extension.  
Description of the research team: 
The research focus in the division is on the basic biology of glial cells in the central nervous system, specifically astrocytes, and their role in several neurological and neuropsychiatric diseases, including stroke, spinal cord injury, epilepsy, tremor, ALS, depression and schizophrenia.  
Description of the project: 
Most neurodegenerative diseases, including Alzheimer’s disease (AD), are linked with the accumulation of misfolded or hyperphosphorylated proteins. The discovery of a novel macroscopic clearance system – the brain glymphatics – posit the existence of a functional drainage system that can transport proteins and extracellular fluid from the brain in a manner similar to peripheral organs. For this position, the specific focus is the determination of glymphatics efflux pathways – as well as its connections to the peripheral lymphatics.  
Our research is aimed at providing new insights into how normal aging and AD affect 
glymphatic clearance. By the identification of bottlenecks on glymphatic clearance, we sought to delineate therapeutic strategies to ameliorate clearance and minimize neural function impairment. 
We are looking for a ‪highly motivated person to perform primarily surgeries in rodents (mice and rats) in order to track glymphatic dynamics and efflux pathways, histology and imaging processing.  
The workflow 
Rodent microsurgery  
Glymphatic system analysis: injection of CSF tracers, tissue harvesting and histology 
Optical (epifluorescence and confocal) and electron microscopy analysis 
Tissue clearing and image processing  
We expect you to be a highly motivated and ambitious scientist with a PhD degree in Neurobiology or equivalent 
We expect you have thorough experience within: 
Glial neurobiology 
Stereotaxic surgeries  
Cell biology 
Experience with image processing of large volume data (advanced knowledge of FIJI/ImageJ and Imaris) 
Histology, immunochemistry 
Molecular biology: DNA and RNA isolation and purification, DNA cloning, in situ hybridization (ISH and FISH), protein analysis, ELISA 
Epifluorescence, confocal and electron microscopy 
Good communication skills in English, both orally and written, is a prerequisite. 
Place of employment 
The employment is at CTN, located at Panum Institute at the University of Copenhagen. The center is newly established and has well equipped laboratories with excellent facilities within neuroscience.  
Terms of employment 
The position is covered by the Memorandum on Job Structure for Academic Staff. Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. 
Application procedure: 
The application must be submitted in English by clicking “Apply online” below.  
It must include the following: 
Curriculum vitae 
Brief statement of research experience and interests 
Full publication list 
Reference contacts 
Application deadline: 
31 December 2017 
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. Information about the recruitment process can be found here: http://employment.ku.dk/faculty/recruitment-process/   
The deadline for applications is one month from the start of advertisement. 
Further information about the Division of Glial Disease and Therapeutics can be found at: http://ctn.ku.dk/research/nedergaard_laboratory/ 
Inquiries about the position can be made to Center Administrator Ann Christensen, ann.christensen@sund.ku.dk

The University of Copenhagen encourages all interested applicants to apply for this postition.

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.


Ann Lee Berger Christensen


Application deadline: 31-12-2017
Employment start: Start as soon as possible
Working hours: Full time
Department/Location: Center for Translational Neuromedicine

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