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Postdoctoral positions in DNA damage signaling

Novo Nordisk Foundation Center for Protein Research, University of Copenhagen 
Mailand Group 
 
Two postdoctoral positions (for a duration of 2 years, with the possibility of extension for up to an additional 2 years) are available in the Ubiquitin Signaling Group headed by Prof. Niels Mailand at Novo Nordisk Foundation Center for Protein Research (CPR – www.cpr.ku.dk), University of Copenhagen, Denmark.
 
Novo Nordisk Foundation Center for Protein Research (CPR) 
CPR was established in 2007 at the Faculty of Health and Medical Sciences, University of Copenhagen, to promote basic and applied discovery research on human proteins of medical relevance. The Center is a strong hub for research on genome stability maintenance and human disease. The scientific environment at CPR, located in central Copenhagen, is highly international, with approx. 30 different nationalities currently represented. The Center comprises modern laboratories and excellent facilities within protein science. Seminars with high-profile international speakers and regular internal research seminars are organized within the Center.  
 
Mailand Laboratory 
Research in the Mailand lab aims to understand how ubiquitin, ubiquitin-like modifiers and other post-translational protein modifications orchestrate and regulate cellular responses to DNA damage and replication stress. We combine systems-wide proteomics- and functional genomics-based approaches with methods within cell biology, biochemistry and advanced imaging to identify and functionally characterize signalling responses that protect genome stability in mammalian cells. We offer a vibrant, ambitious and highly international research environment, as well as access to cutting-edge facilities within protein science, including state-of-the-art proteomics and microscopy platforms. 
 
For more information please visit: http://www.cpr.ku.dk/research/proteinsignaling/mailand/ 
 
Job description and projects 
The candidates will join an ERC-funded team investigating the regulatory signalling processes that enable cells to overcome DNA damage and replication stress, which are major sources of genomic instability that can lead to cancer and other severe pathologies. Using advanced proteomics-based screening approaches we are now able to comprehensively map the proteins recruited to sites of DNA damage and replication stress, providing unparalleled systems-wide insights into the dynamics and scope of cellular factors that act directly in the context of the lesions to safeguard genome stability. The projects aim to mechanistically characterize the functions of prospective new components of genome stability maintenance pathways that we have identified in such screens. For this, the candidates will apply a broad panel of cell-, biochemistry- and microscopy-based methodologies and functional assays. The successful candidates will also be involved in ongoing efforts to interrogate the orchestration of replication stress responses and DNA damage signalling by means of mass spectrometry- and/or CRISPR/Cas9-based systems-wide screens. The precise contents of the projects will be decided after discussions with the selected candidates. 
 
Qualifications 
We are looking for highly motivated and ambitious candidates with: 
  • A PhD degree and track record in the life sciences (biochemistry, cell biology or related)
  • Documented publication record, including at least one publication as first author in a peer-reviewed international journal 
  • Experience in a relevant research area (genome stability, signaling mechanisms, or related). Experience with genomics- or proteomics-based screening technology would be a further advantage.   
  • An open-minded, flexible and enthusiastic personality and good collaboration skills 
Terms of salary and employment 
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and the Danish Confederation of Professional Associations (AC). The position is covered by the Job Structure for Academic Staff at Universities 2013. Currently, the monthly salary is around 32,700 – 34,400 DKK (around 4,300€) plus a 17.1% pension contribution.  
 
Application and deadline 
The application must be submitted in English, by clicking on the “Apply online” button below, and must include the following: 
  • Application and cover letter
  • Curriculum Vitae 
  • Diplomas (all relevant certificates collated into one file) 
  • List of publications 
  • References 
  • A maximum of 3 publications 
After the deadline, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. Applicants are notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on his/her assessment. You may read about the recruitment process at http://employment.ku.dk. CPR and the University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates, regardless of personal background.
 
Deadline for application: 22 September 2017
 
For additional information about the positions, please contact Prof. Niels Mailand (email: niels.mailand@cpr.ku.dk). 
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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

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Niels Mailand

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Application deadline: 24-09-2017
Employment start: Start as soon as possible
Working hours: Full time
Department/Location: Novo Nordisk Foundation Center for Protein Research

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