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Postdoctoral positions in clinical proteomics

Postdoctoral positions in clinical proteomics

Postdoctoral stipends are available in the clinical proteomics group at The Novo Nordisk Foundation Center for Protein Research (CPR – www.cpr.ku.dk). The Center has been established at the Faculty of Health and Medical Sciences, University of Copenhagen to promote basic and applied discovery research on human proteins of medical relevance. The Center comprises a wide range of expertise and resources including proteomics, protein production and characterization in disease mechanisms. The clinical proteomics group is led by Prof. Dr. Matthias Mann, a leading authority in mass spectrometry-based proteomics with more than 180,000 citations and an h-factor of 199 (Google Scholar).  

The clinical proteomics group develops and applies proteomics technology with a goal of understanding health and disease and making an impact in public health. We work in close synergy with the Proteomics and Cell Signaling group at the Max-Planck Institute of Biochemistry in Munich, which is also led by Prof. Mann as well as other groups at the CPR, especially Prof. Chunaram Choudhary in cell signaling and Prof. Søren Brunak in bioinformatics and patient record mining.

Our particular focus is on the plasma proteome in the context of metabolic disorders such as diabetes. To this end, we are developing technology for the rapid and large scale analysis of plasma proteomes using mass spectrometry-based proteomics to a depth of at least 1000 proteins per patient. We have termed this approach ‘plasma proteome profiling’ and our goal is to develop it into a comprehensive tool for medical diagnostics (Philip Geyer et al, Cell Systems 2016). We are currently looking for several talented and motivated post-doctoral fellows with experience in the core or associated technologies to join a young and dynamic team in beautiful Copenhagen.

For more information about the research group please visit:

http://www.cpr.ku.dk/research/proteomics/mann-group/

Project Description

The clinical proteomics group was established with a generous grant from the Novo-Nordisk Foundation in December 2015. At this point, we have developed part of the technology required for deep plasma proteomics and we have started to apply this technology to small and medium scale clinical studies. Characterizing the plasma proteome in metabolic diseases such as diabetes and life style (diet and exercise) are current priorities. Longer term we have many other interests such as applying the technology in the context of patient stratification, assessing the efficacy of intervention, developing biomarkers in neurodegenerative diseases, to name just a few.

The successful candidates should be able to contribute to the overall effort for instance by focused efforts in technology development or development of the overall plasma proteomics workflow, including systems biology analysis. They could also pursue plasma proteomics profiling on studies in particular biomedical areas, including diabetes, or any of the disease with a metabolic risk component. These studies will usually already have been performed by a collaborating group and the candidate will contribute by analyzing plasma proteomes and making discoveries from the obtained results. Depending on the case, we also expect the candidate to perform biological follow up experiments on potential biomarkers or patterns.

Projected start date: Autumn 2017

Qualifications

  • The candidate is required to have a PhD or equivalent degree in the natural or medical science.
  • Excellent scientific track record, including at least one publication as first author in a high quality, peer reviewed international journal.
  • A good molecular biology/molecular biomedicine background is required.
  • Experience with mass spectrometry based proteomics is highly desired.
  • Experience and interest in technology development, especially in MS-based proteomics are advantageous.
  • Experience with clinical proteomics is likely desirable.
  • The candidate needs to be able to work effectively in an international and multidisciplinary team.
  • Demonstrated writing and other communication skills are advantageous.

Place of employment and work

The employment is at CPR (www.cpr.ku.dk), University of Copenhagen, located in central Copenhagen. The research environment at CPR is vibrant and ambitious but also supportive. Currently about 30 different nationalities are represented. The Center comprises modern laboratories and state-of-the-art facilities in protein science and related areas. The institute regularly organizes seminars with high-profile international speakers as well as other events.

Terms of salary and employment

Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary is around 32,350 – 34,060 DKK (around 4,250€) plus 17.1 % in pension contribution. The duration of the positions will be 2 years.

Application

Please submit your application electronically via:

http://employment.ku.dk/faculty/

Your application should include the following documents:

  • Letter of motivation for the application
  • Curriculum vitae, incl. education and experience
  • List of publications
  • Letters of recommendation
  • Names and contact details for at least two referees

For further information about the position, please contact CPR:

Jobs@cpr.ku.dk 

Deadline for application: 18 June 2017

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk    


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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

Matthias Mann
E-mail: jobs@cpr.ku.dk

Info

Application deadline: 18-06-2017
Employment type: Limited period
Employment start: 18-06-2017
Department/Location: Center for Protein Research

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