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PhD Fellowship in Computational Chemistry / Peptide modelling

The Computational Drug Design Group (Gloriam group), Department of Drug Design and Pharmacology, University of Copenhagen wishes to employ a PhD Fellow in Scientific Database Development. The project starts December 2017 or January 2018 and lasts for 3 years. 
 
The Gloriam group (gloriamgroup.org) conducts bioinformatics, scientific data analysis and computational drug design, tightly integrated with leading chemists and pharmacologists, and structure-function studies of G protein-coupled receptors (GPCRs) – one of the largest drug target families. The group also heads the GPCR community’s main database and web server, GPCRdb (GPCRdb.org) serving ~1700 monthly users. The group currently has 15 members, funded mainly by an ERC Starting Grant and Lundbeck Foundation Fellowship, and has in the last 1,5 years published in e.g. Nature, Nature Chemistry, Nucleic Acids Research and Bioinformatics. 
 
Project 
The PhD scholarship is part of a large biomedical project entitled "Novel principles for targeting intracellular receptor signaling pathways in the brain. The specific project will focus on identification and pharmacological/biophysical characterization of compounds targeting intracellular G proteins. The project will study chemical derivatives of already known inhibitors from natural products as well as screen for novel inhibitors based on virtual screening compound libraries. Compounds will be tested on representative G protein-coupled receptors signaling through the four major G protein families using a range of mammalian cell based assays. 
The mechanism-of-action of the most interesting compounds will be studied by e.g. mutagenesis. Finally, it will be studied if the inhibitors retain their activity on human mutations causing diseases such as cancers and hypoparathyroidism. 
 
General job description 
  • Manage, carry through and conclude your research project 
  • Actively participate in PhD courses 
  • Write scientific articles and finalise your PhD thesis 
  • Participate in international congresses 
  • Conduct a 1-6 month research stay in another group
  • Teach and disseminate your research 
Qualification requirements 
Mandatory requirements 
  • A MSc in in chemistry, pharmaceutical sciences, bioinformatics, molecular biology or similar topic 
  • Experience of computational methods and peptide/protein sequence analysis 
  • Demonstrated ability to independently learn new concepts and solve biological problems 
  • Fluency in English and experience in writing scientific texts 
Additional meriting qualifications 
Experience of, and skills in: 
  • G protein-coupled receptors 
  • Analysis of molecular structures and interactions 
  • The Schrödinger Drug Discovery Suite, PyMOL 
  • Shell scripting, programming in Python or other languages 
Key criteria for the assessment of applicants 
  • Professional qualifications relevant to the project 
  • Relevant work experience 
  • Publications 
  • Other professional activities 
  • Language skills 
  • Good interpersonal skills 
Terms of employment 
The post will be filled according to the Agreement between the Danish Ministry of Finance and the Danish Confederation of Professional Associations. The post is covered by the Protocol on Job Structure. 
 
Questions 
For further information about the post, please contact Associate Professor David E. Gloriam via david.gloriam@sund.ku.dk or (+45) 93 56 54 49. 
 
Application 
The application, in English, must be submitted in the online application form. The application must include the following appendices: 
Appendix 1: curriculum vitae with documentation of education. 
Appendix 2: a complete list of publications and list of submitted appendices. 
Appendix 3: documentation of additional research qualifications. 
 
In addition to the material the applicant wishes to be included in the assessment, the Assessment Committee may include further material in their assessment of the applicant, such as reference letters. In such circumstances, it is the responsibility of the applicant, on request, to send the material to the Committee. Following processing of the application, any application material sent will be destroyed. 
The applicant will be assessed according to the Ministry of Science Technology and Innovation Executive Order no 284 of 25. April 2008. 
 
University of Copenhagen and Denmark 
Founded in 1479, the University of Copenhagen is the oldest university in Denmark. With 39,000 students and 10,000 employees, it is among the largest universities in Scandinavia and one of the highest ranking in Europe. The University consists of six faculties, which cover Health and Medical Sciences, Humanities, Law, Science, Social Sciences and Theology. Read more at www.sund.ku.dk and www.drug.ku.dk.  
Copenhagen is a modern capital with plenty of opportunities in culture, design, architecture, restaurants and a diverse nightlife. At the same time, the city offers beaches, beautiful parks and green nature areas, and the Copenhageners bike everywhere. The Danish society prioritises a good work-life balance, and the work culture is well adjusted for families with children. Read more at http://ism.ku.dk/.  
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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

David E. Gloriam

Contact

Flemming Steen Jørgensen
E-mail: fsj@sund.ku.dk

Info

Application deadline: 20-10-2017
Employment start: 01-12-2017
Working hours: Full time
Department/Location: Institut for Lægemiddeldesign og Farmakologi

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